Publications
Patents
2023
Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space
Lolicato F#, Steringer JP, Saleppico R, Beyer D,
Fernandez-Sobaberas J, Unger S, Klein S, Riegerová P, Wegehingel
S, Müller HM, Freund C, Hof, M, Šachl R, ChlandaP, Vattulainen
I, and Nickel W (2023). eLife.
Link to the paper
Determining the Functional Oligomeric State of Membrane-Associated Protein Oligomers Forming Membrane Pores on Giant Lipid Vesicles
Singh V, Macharová S, Riegerová P, Steringer J P, Müller H-M,
Lolicato F, Nickel W, Hof M, and Šachl R (2023). Anal. Chem.
Link to the paper
IFITM3 blocks viral entry by sorting lipids and stabilizing hemifusion
Klein S, Golani G, Lolicato F*, Beyer D, Herrmann A,
Wachsmuth-Melm M, Reddmann N, Brecht R, Lahr C, Hosseinzadeh M,
Kolovou A, Schorb M, Schwab Y, Brügger B, Nickel W, Schwarz U S,
Chlanda P (2023). Cell Host&Microbe.
Link to the paper
The Ebola Virus VP40 Matrix Undergoes Endosomal Disassembly Essential for Membrane Fusion
Winter S. L, Golani G, Lolicato F, Vallbracht M, Thiyagarajah K,
Ahmed S S, Lüchtenborg C, Fackler O T, Brügger B, Hoenen T,
Nickel W, Schwarz U S, Chlanda P. (2023). EMBO J.
Link to the paper
In vivo characterization of the bacterial intramembrane-cleaving protease RseP using the heme binding tag-based assay iCliPSpy
Kupke T, Götz R M, Richter F M, Beck R, Lolicato F, Nickel W,
Hopf C and Brügger B. (2023). Commun. Biol.
Link to the paper
2022
Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2
Lolicato F#, Saleppico R, Griffo A, Meyer A, Scollo F,
Pokrandt B, Müller HM, Ewers H, Hähl H, Fleury JB,
Seemann R, Hof M, Brügger B, Jacobs K, Vattulainen I,
Nickel W (2022). J. Cell. Biol.
Link to the paper
Dimerization of the Pulmonary Surfactant Protein C in a Membrane Environment
Korolainen H, Lolicato F, Enkavi G, Pérez-Gil J, Kulig W,
Vattulainen I. (2022). PLoS One.
Link to the paper
A Role for Liquid-Ordered Plasma Membrane Nanodomains Coordinating the Unconventional Secretory Pathway of Fibroblast Growth Factor 2?
Lolicato F#, Nickel W. (2022). Front. Cell Dev. Biol.
Link to the paper
A Unifying Framework for Amyloid-Mediated Membrane Damage: The Lipid-Chaperone Hypothesis
Tempra C, Scollo F, Pannuzzo M, Lolicato F#, La Rosa C. A
(2022). BBA-Proteins Proteom.
Link to the paper
2021
The Role of Alpha-Helix on the Structure-Targeting Drug Design of Amyloidogenic Proteins
Tempra C, La Rosa C, Lolicato F. (2021). Chem. Phys. Lipids.
Link to the paper
2020
Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins
Sciacca M F, Lolicato F*, Tempra C, Scollo F, Sahoo B R, Watson
M D, García-Viñuales, S, Milardi D, Raudino A, Lee, J. C,
Ramamoorthy A, La Rosa C. (2020). ACS Chem. Neurosci.
Link to the paper
The Na,K-ATPase Acts Upstream of Phosphoinositide PI(4,5)P2 Facilitating Unconventional Secretion of Fibroblast Growth Factor 2
Legrand C, Saleppico R, Sticht, J, Lolicato F, Müller H-M,
Wegehingel S, Dimou E, Steringer J P, Ewers H, Vattulainen I,
Freund C, Nickel W. (2020). Commun. Biol.
Link to the paper
Mcl-1 and Bok Transmembrane Domains: Unexpected Players in the Modulation of Apoptosis
Lucendo E, Sancho M, Lolicato F, Javanainen M, Kulig W, Leiva D,
Duart G, Andreu-Fernández V, Mingarro I, Orzáez M. (2020). Proc.
Natl. Acad. Sci. USA.
Link to the paper
Cholesterol Localization around the Metabotropic Glutamate Receptor 2
Kurth M, Lolicato F, Sandoval-Perez A, Amaya-Espinosa H,
Teslenko A, Sinning I, Beck R, Brügger B, Aponte-Santamaría C.
(2020). J. Phys. Chem. B.
Link to the paper
Modulating Aβ Aggregation by Tyrosol-Based Ligands: The Crucial Role of the Catechol Moiety
Romanucci V, García-Viñuales S, Tempra C, Bernini R, Zarrelli A,
Lolicato F#, Milardi D, Di Fabio G. (2020). Biophys. Chem.
Link to the paper
Membrane-Dependent Binding and Entry Mechanism of Dopamine into Its Receptor
Lolicato F, Juhola H, Zak A, Postila P. A, Saukko A, Rissanen S,
Enkavi G, Vattulainen I, Kepczynski M, Róg T. (2020). ACS Chem.
Neurosci.
Link to the paper
Symmetry-Breaking Transitions in the Early Steps of Protein Self-Assembly
La Rosa C, Condorelli M, Compagnini G, Lolicato F, Milardi D, Do
T N, Karttunen M, Pannuzzo M, Ramamoorthy A, Fraternali F, Collu
F, Rezaei H, Strodel B, Raudino A. (2020). Eur. Biophys. J.
Link to the paper
2019
The Role of Temperature and Lipid Charge on Intake/Uptake of Cationic Gold Nanoparticles into Lipid Bilayers
Lolicato F, Joly L, Martinez‐Seara H, Fragneto G, Scoppola E,
Baldelli Bombelli F, Vattulainen I, Akola J, Maccarini M.
(2019). Small.
Link to the paper
The Devil Is in the Details: What Do We Really Track in Single-Particle Tracking Experiments of Diffusion in Biological Membranes?
Gurtovenko A A, Javanainen M, Lolicato F, Vattulainen I. (2019).
J. Phys. Chem. Lett.
Link to the paper
2018
Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes
Scollo F, Tempra C, Lolicato F, Sciacca M F. M, Raudino A,
Milardi D, La Rosa C. (2018). J. Phys. Chem. Lett.
Link to the paper
Negatively Charged Gangliosides Promote Membrane Association of Amphipathic Neurotransmitters
Juhola H, Postila P. A, Rissanen S, Lolicato F, Vattulainen I,
Róg T. (2018). Neurosci.
Link to the paper
Detection and Characterization at NM Concentration of Oligomers Formed by HIAPP, Aβ(1–40) and Their Equimolar Mixture Using SERS and MD Simulations
D’Urso L, Condorelli M, Puglisi O, Tempra C, Lolicato F,
Compagnini G, La Rosa C. (2018). Phys. Chem. Chem. Phys.
Link to the paper
2017
DoGlycans –Tools for Preparing Carbohydrate Structures for Atomistic Simulations of Glycoproteins, Glycolipids, and Carbohydrate Polymers for GROMACS
Danne R, Poojari C, Martinez-Seara H, Rissanen S, Lolicato F,
Róg T, Vattulainen I. (2017). J. Chem. Inf. Model.
Link to the paper
Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry
Sciacca, Michele. F. M, Romanucci V, Zarrelli A, Monaco I,
Lolicato F, Spinella N, Galati C, Grasso G, D’Urso L, Romeo M,
Diomede L, Salmona M, Bongiorno C, Di Fabio G, La Rosa C,
Milardi D. (2017). ACS Chem. Neurosci.
Link to the paper
Key Steps in Unconventional Secretion of Fibroblast Growth Factor 2 Reconstituted with Purified Components
Steringer J P, Lange S, Čujová S, Šachl R, Poojari C, Lolicato
F, Beutel O, Müller H-M, Unger S, Coskun Ü, Honigmann A,
Vattulainen I, Hof M, Freund C, Nickel W. (2017). eLife.
Link to the paper
2016
The Role of Cholesterol in Driving IAPP-Membrane Interactions
Sciacca M F. M, Lolicato F, Di Mauro G, Milardi D, D’Urso L,
Satriano C, Ramamoorthy A, La Rosa C. (2016). Biophys. J.
Link to the paper
Lipid-Assisted Protein Transport: A Diffusion-Reaction Model Supported by Kinetic Experiments and Molecular Dynamics Simulations
La Rosa C, Scalisi S, Lolicato F, Pannuzzo M, Raudino A. (2016).
J. Chem. Phys.
Link to the paper
2015
Resveratrol Interferes with the Aggregation of Membrane-Bound Human-IAPP: A Molecular Dynamics Study
Lolicato F, Raudino A, Milardi D, La Rosa C. (2015). Eur. J.
Med. Chem.
Link to the paper