bioRxiv 2026
High-Throughput Characterization of Trends in Transmembrane Helix Partitioning into Membrane Domains
Jonathan Thelen, Melanie Koenig, Maisa Vuorte, Jarkko Liimatainen, Matti Javanainen, Fabio Lolicato
Publications
43
Patents
1
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Updated June 2026
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23
Total citations
1578
Since 2021
1278
i10-index
31
Citations
Citations per year
2016
12
2017
16
2018
65
2019
55
2020
141
2021
170
2022
228
2023
218
2024
210
2025
295
2026
148
Publications
Papers per year
2015
1
2016
2
2017
3
2018
3
2019
2
2020
7
2021
1
2022
4
2023
5
2024
5
2025
8
2026
2
Highlights
Selected Publications
Journal of Colloid and Interface Science 2026
How lipid composition shapes the nanostructural interaction of tumor biomarker alpha-fetoprotein and bovine serum albumin with model membranes
Beatrice Barletti, Melanie König, Nicoló Paracini, Giovanna Fragneto, Jean-Pierre Alcaraz, Andrew Nelson, Isabelle Vilgrain, Donald K. Martin, Fabio Lolicato, Marco Maccarini
Nature Communications 2025
Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2
Manpreet Kaur, Fabio Lolicato, Walter Nickel
Chemistry and Physics of Lipids 2021
The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins
Carmelo Tempra, Carmelo La Rosa, Fabio Lolicato
bioRxiv 2025
Nanoscale PI(4,5)P2 partitioning driven by FGF2 oligomerization triggers membrane pore formation
Alessandra Griffo, Daniel Beyer, Jaime Fernández Sobaberas, Melanie König, Zeynep Kilcan, Manpreet Kaur, Eleonora Margheritis, Katia Cosentino, Petra Riegerová, Martin Hof, Radek Šachl, Walter Nickel, Fabio Lolicato
Journal of Cell Biology 2022
Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2
Fabio Lolicato, Roberto Saleppico, Alessandra Griffo, Annalena Meyer, Federica Scollo, Bianca Pokrandt, Hans-Michael Müller, Helge Ewers, Hendrik Hähl, Jean-Baptiste Fleury, Ralf Seemann, Martin Hof, Britta Brügger, Karin Jacobs, Ilpo Vattulainen, Walter Nickel
eLife 2024
Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space
Fabio Lolicato, Julia P. Steringer, Roberto Saleppico, Daniel Beyer, Jaime Fernandez-Sobaberas, Sebastian Unger, Steffen Klein, Petra Riegerová, Sabine Wegehingel, Hans-Michael Müller, Xiao J. Schmitt, Shreyas Kaptan, Christian Freund, Martin Hof, Radek Šachl, Petr Chlanda, Ilpo Vattulainen, Walter Nickel
Full List
Publications
2026
2 papers bioRxiv 2026
High-Throughput Characterization of Trends in Transmembrane Helix Partitioning into Membrane Domains
Jonathan Thelen, Melanie Koenig, Maisa Vuorte, Jarkko Liimatainen, Matti Javanainen, Fabio Lolicato
Journal of Colloid and Interface Science 2026
How lipid composition shapes the nanostructural interaction of tumor biomarker alpha-fetoprotein and bovine serum albumin with model membranes
Beatrice Barletti, Melanie König, Nicoló Paracini, Giovanna Fragneto, Jean-Pierre Alcaraz, Andrew Nelson, Isabelle Vilgrain, Donald K. Martin, Fabio Lolicato, Marco Maccarini
2025
8 papers Nature Communications 2025
Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2
Manpreet Kaur, Fabio Lolicato, Walter Nickel
bioRxiv 2025
Nanoscale PI(4,5)P2 partitioning driven by FGF2 oligomerization triggers membrane pore formation
Alessandra Griffo, Daniel Beyer, Jaime Fernández Sobaberas, Melanie König, Zeynep Kilcan, Manpreet Kaur, Eleonora Margheritis, Katia Cosentino, Petra Riegerová, Martin Hof, Radek Šachl, Walter Nickel, Fabio Lolicato
Nature Communications 2025
Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching
Martin Würtz, Giulia Tonon, Bram J. A. Vermeulen, Maja Zezlina, Qi Gao, Annett Neuner, Angelika Seidl, Melanie König, Maximilian Harkenthal, Sebastian Eustermann, Sylvia Erhardt, Fabio Lolicato, Elmar Schiebel, Stefan Pfeffer
Protein Science 2025
Structural insights into SARS-CoV-2 nonstructural protein 4 (nsp4) biogenesis
José M. Acosta-Cáceres, Fabio Lolicato, Laura Gadea-Salom, Juan Ortiz-Mateu, Diego Belda, Luis Martínez-Gil, María Jesús García-Murria, Ismael Mingarro
Traffic 2025
Beyond the Secretory Pathway: New Insights Into Protein Release
Ruey-Hwa Chen, Antonio J. Costa-Filho, Jayanta Debnath, Thierry Galli, Liang Ge, Deborah Goberdhan, Wei Guo, Kangmin He, Ralf Jacob, Tiebang Kang, Min Goo Lee, Lian Li, Fabio Lolicato, Jun Lu, Vivek Malhotra, Walter Nickel, and others
ACS Central Science 2025
The Martini 3 Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior
Kasper B. Pedersen, Helgi I. Ingólfsson, Daniel P. Ramirez-Echemendia, Luís Borges-Araújo, Mikkel D. Andreasen, and others, including Fabio Lolicato
Antioxidants 2025
Synthesis of Ethylphosphonate Curcumin Mimics: Substituents Allow Switching Between Cytotoxic and Cytoprotective Activities
Valeria Romanucci, Rita Pagano, Solveigh C. Koeberle, Andreas Koeberle, Minh Bui Hoang, Sonia Di Gaetano, Domenica Capasso, Michele Francesco Maria Sciacca, Valeria Lanza, Carmelo Tempra, Fabio Lolicato, Armando Zarrelli, Danilo Milardi, Giovanni Di Fabio
Faraday Discussions 2025
Does plasma membrane transbilayer asymmetry coupled to lipid nanodomains drive fast kinetics of FGF2 membrane translocation into the extracellular space?
Fabio Lolicato, Manpreet Kaur, Ana Marija Knez, Roberto Saleppico, Walter Nickel
2024
5 papers Journal of Biological Chemistry 2024
Phosphoinositide switches in cell physiology - From molecular mechanisms to disease
Fabio Lolicato, Walter Nickel, Volker Haucke, Michael Ebner
eLife 2024
SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions
Anna Kádková, Jacqueline Murach, Maiken Østergaard, Andrea Malsam, Jörg Malsam, Fabio Lolicato, Walter Nickel, Thomas H. Söllner, Jakob Balslev Sørensen
Nature Communications 2024
Overlay databank unlocks data-driven analyses of biomolecules for all
Anne M. Kiirikki, Hanne S. Antila, Lara S. Bort, Pavel Buslaev, Fernando Favela-Rosales, Tiago Mendes Ferreira, Patrick F. J. Fuchs, Rebeca Garcia-Fandino, Ivan Gushchin, Batuhan Kav, and others, including Fabio Lolicato
eLife 2024
Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space
Fabio Lolicato, Julia P. Steringer, Roberto Saleppico, Daniel Beyer, Jaime Fernandez-Sobaberas, Sebastian Unger, Steffen Klein, Petra Riegerová, Sabine Wegehingel, Hans-Michael Müller, Xiao J. Schmitt, Shreyas Kaptan, Christian Freund, Martin Hof, Radek Šachl, Petr Chlanda, Ilpo Vattulainen, Walter Nickel
RSC Advances 2024
Mechanics of biomimetic free-standing lipid membranes: insights into the elasticity of complex lipid compositions
Alessandra Griffo, Carola Sparn, Fabio Lolicato, Friederike Nolle, Navid Khangholi, Ralf Seemann, Jean-Baptiste Fleury, Martin Brinkmann, Walter Nickel, Hendrik Hähl
2023
5 papers bioRxiv 2023
The sterol transporter STARD3 transports sphingosine at ER-lysosome contact sites
Pia Hempelmann, Fabio Lolicato, Andrea Graziadei, Ryan D. R. Brown, Sarah Spiegel, Juri Rappsilber, Walter Nickel, Doris Höglinger, Denisa Jamecna
EMBO Journal 2023
The Ebola virus VP40 matrix layer undergoes endosomal disassembly essential for membrane fusion
Sophie L. Winter, Gonen Golani, Fabio Lolicato, Melina Vallbracht, Keerthihan Thiyagarajah, Samy Sid Ahmed, Christian Lüchtenborg, Oliver T. Fackler, Britta Brügger, Thomas Hoenen, Walter Nickel, Ulrich S. Schwarz, Petr Chlanda
Analytical Chemistry 2023
Determining the Functional Oligomeric State of Membrane-Associated Protein Oligomers Forming Membrane Pores on Giant Lipid Vesicles
Vandana Singh, Sabína Macharová, Petra Riegerová, Julia P. Steringer, Hans-Michael Müller, Fabio Lolicato, Walter Nickel, Martin Hof, Radek Šachl
Cell Host & Microbe 2023
IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion
Steffen Klein, Gonen Golani, Fabio Lolicato, Carmen Lahr, Daniel Beyer, Alexia Herrmann, Moritz Wachsmuth-Melm, Nina Reddmann, Romy Brecht, Mehdi Hosseinzadeh, Androniki Kolovou, Jana Makroczyova, Sarah Peterl, Martin Schorb, Yannick Schwab, Britta Brügger, Walter Nickel, Ulrich S. Schwarz, Petr Chlanda
Communications Biology 2023
In vivo characterization of the bacterial intramembrane-cleaving protease RseP using the heme binding tag-based assay iCliPSpy
Thomas Kupke, Rabea M. Götz, Florian M. Richter, Rainer Beck, Fabio Lolicato, Walter Nickel, Carsten Hopf, Britta Brügger
2022
4 papers Journal of Cell Biology 2022
Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2
Fabio Lolicato, Roberto Saleppico, Alessandra Griffo, Annalena Meyer, Federica Scollo, Bianca Pokrandt, Hans-Michael Müller, Helge Ewers, Hendrik Hähl, Jean-Baptiste Fleury, Ralf Seemann, Martin Hof, Britta Brügger, Karin Jacobs, Ilpo Vattulainen, Walter Nickel
PLOS ONE 2022
Dimerization of the pulmonary surfactant protein C in a membrane environment
Hanna Korolainen, Fabio Lolicato, Giray Enkavi, Jesús Pérez-Gil, Waldemar Kulig, Ilpo Vattulainen
Frontiers in Cell and Developmental Biology 2022
A Role for Liquid-Ordered Plasma Membrane Nanodomains Coordinating the Unconventional Secretory Pathway of Fibroblast Growth Factor 2?
Fabio Lolicato, Walter Nickel
Biochimica et Biophysica Acta - Proteins and Proteomics 2022
A unifying framework for amyloid-mediated membrane damage: The lipid-chaperone hypothesis
Carmelo Tempra, Federica Scollo, Martina Pannuzzo, Fabio Lolicato, Carmelo La Rosa
2021
1 papers Chemistry and Physics of Lipids 2021
The role of alpha-helix on the structure-targeting drug design of amyloidogenic proteins
Carmelo Tempra, Carmelo La Rosa, Fabio Lolicato
2020
7 papers ACS Chemical Neuroscience 2020
Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins
Michele F. Sciacca, Fabio Lolicato, Carmelo Tempra, Federica Scollo, Bikash R. Sahoo, Matthew D. Watson, Sara García-Viñuales, Danilo Milardi, Antonio Raudino, Jennifer C. Lee, Ayyalusamy Ramamoorthy, Carmelo La Rosa
Biophysical Chemistry 2020
Modulating Aβ aggregation by tyrosol-based ligands: The crucial role of the catechol moiety
Valeria Romanucci, Sara García-Viñuales, Carmelo Tempra, Roberta Bernini, Armando Zarrelli, Fabio Lolicato, Danilo Milardi, Giovanni Di Fabio
Communications Biology 2020
The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P2 facilitating unconventional secretion of Fibroblast Growth Factor 2
Cyril Legrand, Roberto Saleppico, Jana Sticht, Fabio Lolicato, Hans-Michael Müller, Sabine Wegehingel, Eleni Dimou, Julia P. Steringer, Helge Ewers, Ilpo Vattulainen, Christian Freund, Walter Nickel
Journal of Physical Chemistry B 2020
Cholesterol Localization around the Metabotropic Glutamate Receptor 2
Markus Kurth, Fabio Lolicato, Angelica Sandoval-Perez, Helman Amaya-Espinosa, Alexandra Teslenko, Irmgard Sinning, Rainer Beck, Britta Brügger, Camilo Aponte-Santamaría
ACS Chemical Neuroscience 2020
Membrane-Dependent Binding and Entry Mechanism of Dopamine into Its Receptor
Fabio Lolicato, Hanna Juhola, Agata Zak, Pekka A. Postila, Annina Saukko, Sami Rissanen, Giray Enkavi, Ilpo Vattulainen, Mariusz Kepczynski, Tomasz Róg
European Biophysics Journal 2020
Symmetry-breaking transitions in the early steps of protein self-assembly
Carmelo La Rosa, Marcello Condorelli, Giuseppe Compagnini, Fabio Lolicato, Danilo Milardi, Trang Nhu Do, Mikko Karttunen, Martina Pannuzzo, Ayyalusamy Ramamoorthy, Franca Fraternali, Francesca Collu, Human Rezaei, Birgit Strodel, Antonio Raudino
PNAS 2020
Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis
Estefanía Lucendo, Mónica Sancho, Fabio Lolicato, Matti Javanainen, Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Fernández, Ismael Mingarro, Mar Orzáez
2019
2 papers Small 2019
The Role of Temperature and Lipid Charge on Intake/Uptake of Cationic Gold Nanoparticles into Lipid Bilayers
Fabio Lolicato, Loic Joly, Hector Martinez-Seara, Giovanna Fragneto, Ernesto Scoppola, Francesca Baldelli Bombelli, Ilpo Vattulainen, Jaakko Akola, Marco Maccarini
Journal of Physical Chemistry Letters 2019
The Devil Is in the Details: What Do We Really Track in Single-Particle Tracking Experiments of Diffusion in Biological Membranes?
Andrey A. Gurtovenko, Matti Javanainen, Fabio Lolicato, Ilpo Vattulainen
2018
3 papers Journal of Physical Chemistry Letters 2018
Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes
Federica Scollo, Carmelo Tempra, Fabio Lolicato, Michele F. M. Sciacca, Antonio Raudino, Danilo Milardi, Carmelo La Rosa
Neuroscience 2018
Negatively Charged Gangliosides Promote Membrane Association of Amphipathic Neurotransmitters
Hanna Juhola, Pekka A. Postila, Sami Rissanen, Fabio Lolicato, Ilpo Vattulainen, Tomasz Róg
Physical Chemistry Chemical Physics 2018
Detection and characterization at nM concentration of oligomers formed by hIAPP, Aβ(1–40) and their equimolar mixture using SERS and MD simulations
Luisa D’Urso, Marcello Condorelli, Orazio Puglisi, Carmelo Tempra, Fabio Lolicato, Giuseppe Compagnini, Carmelo La Rosa
2017
3 papers eLife 2017
Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components
Julia P. Steringer, Sascha Lange, Sabína Čujová, Radek Šachl, Chetan Poojari, Fabio Lolicato, Oliver Beutel, Hans-Michael Müller, Sebastian Unger, Ünal Coskun, Alf Honigmann, Ilpo Vattulainen, Martin Hof, Christian Freund, Walter Nickel
ACS Chemical Neuroscience 2017
Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry
Michele F. M. Sciacca, Valeria Romanucci, Armando Zarrelli, Irene Monaco, Fabio Lolicato, Natalia Spinella, Clelia Galati, Giuseppe Grasso, Luisa D’Urso, Margherita Romeo, Luisa Diomede, Mario Salmona, Corrado Bongiorno, Giovanni Di Fabio, Carmelo La Rosa, Danilo Milardi
Journal of Chemical Information and Modeling 2017
doGlycans – Tools for Preparing Carbohydrate Structures for Atomistic Simulations of Glycoproteins, Glycolipids, and Carbohydrate Polymers for GROMACS
Reinis Danne, Chetan Poojari, Hector Martinez-Seara, Sami Rissanen, Fabio Lolicato, Tomasz Róg, Ilpo Vattulainen
2016
2 papers Biophysical Journal 2016
The Role of Cholesterol in Driving IAPP-Membrane Interactions
Michele F. M. Sciacca, Fabio Lolicato, Giacomo Di Mauro, Danilo Milardi, Luisa D’Urso, Cristina Satriano, Ayyalusamy Ramamoorthy, Carmelo La Rosa
The Journal of Chemical Physics 2016
Lipid-assisted protein transport: A diffusion-reaction model supported by kinetic experiments and molecular dynamics simulations
Carmelo La Rosa, Silvia Scalisi, Fabio Lolicato, Martina Pannuzzo, Antonio Raudino
2015
1 papers European Journal of Medicinal Chemistry 2015
Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study
Fabio Lolicato, Antonio Raudino, Danilo Milardi, Carmelo La Rosa